What could uproot a young woman and move her halfway around the world?
Two words: Laminitis research.
Working with Dr. Pollitt, Melody discovered that receptors designed to receive insulin-like growth factor 1 (IGF-1) may be binding to insulin instead in horses when horses have high levels of insulin.
This groundbreaking discovery may enable scientists to develop strategies to try to block IGF-1 receptors from receiving insulin and prevent the disease from occurring.
The equine foot is very dependent on glucose for metabolism, but it is not dependent on insulin to deliver that glucose. Horses have a large number of IGF-1 receptors in their feet, but no insulin receptors. Pollitt’s team theorizes that these IGF-1 receptors are being stimulated by insulin that mimics insulin-like growth factor 1 and is binding to these receptors.
When this happens, the lamina stretch, and laminitis occurs.
To continue her research, Melody accepted a post-doctoral position at Oklahoma State University College of Veterinary Medicine. Even though she has only been there a few months, she’s hard at work.
Before Melody left Australia, she accepted a challenge to explain her PhD research in plain English to an audience who knew nothing about laminitis or horses--in three minutes.
Melody’s
research at Oklahoma State is funded by your donations through the
Animal Health Foundation. Will her research make a difference to horses
at risk for laminitis? The Animal Health Foundation believes it will.
Here’s a brief description of the project we are funding, with your
help:
Investigation of the regulation of glucose transport and insulin signaling pathways in the insulin-induction model of laminitis
Problems
associated with abnormal glucose (i.e. sugar) and insulin processes are
of particular interest and concern in horses where a persistently
increased level of insulin in the blood causes the development of
laminitis. This condition is a relatively common one among many breeds.
The current AHF-funded project being
investigated by Drs. Lacombe and de Laat at Oklahoma State University
aims to investigate how glucose transport and insulin signaling are
regulated in the heart, muscle and lamellar tissues (in the feet) of
horses that have laminitis associated with hyperinsulinaemia.
This will
be compared to glucose and insulin regulation in the same tissues of
normal horses.
Why is this important research?
1.
This project will study tissues that have not been previously examined
to assess the pattern of glucose metabolism during very high blood
insulin levels.
2.
The work will build on the limited available data on lamellar
metabolism in horses with insulin-associated laminitis by investigating
new topics such as intracellular signaling and inflammatory pathways in
the foot and how they relate to glucose transport.
3.
Characterization of the changes in glucose transport during conditions
of high insulin will provide new insights into the mechanisms of insulin
resistance in horses and may facilitate the development of novel
therapeutic interventions for the management of metabolic diseases in
horses.
4.
Finally, better understanding of the insulin-signaling processes in the
foot during increased insulin availability will improve our overall
understanding of laminitis.
This may lead to new avenues for disease
treatment and prevention.
The
Animal Health Foundation is encouraged by Melody’s continued
involvement in laminitis research, and in her move to the United States.
We are confident that her research will yield results that will move
our efforts forward and ever closer to our goal of ending this terrible
disease.
Thank you for your support of the Animal Health Foundation’s laminitis research.
